Discovery of a phase-separating small molecule that selectively sequesters tubulin in cells

Phase-separated membraneless organelles or biomolecular condensates play diverse functions in cells, however recapturing their characteristics using small organic molecules has been a challenge. In the present study, cell-lysate-based screening of 843 self-assembling small molecules led to the disco...

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Detalles Bibliográficos
Autores principales: Ado, Genyir, Noda, Naotaka, Vu, Hue T., Perron, Amelie, Mahapatra, Amarjyoti D., Arista, Karla Pineda, Yoshimura, Hideaki, Packwood, Daniel M., Ishidate, Fumiyoshi, Sato, Shin-ichi, Ozawa, Takeaki, Uesugi, Motonari
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9116451/
https://www.ncbi.nlm.nih.gov/pubmed/35694339
http://dx.doi.org/10.1039/d1sc07151c

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9116451/
https://www.ncbi.nlm.nih.gov/pubmed/35694339
http://dx.doi.org/10.1039/d1sc07151c

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