Reduced platelet forces underlie impaired hemostasis in mouse models of MYH9-related disease

MYH9-related disease patients with mutations in the contractile protein nonmuscle myosin heavy chain IIA display, among others, macrothrombocytopenia and a mild-to-moderate bleeding tendency. In this study, we used three mouse lines, each with one point mutation in the Myh9 gene at positions 702, 14...

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Detalles Bibliográficos
Autores principales: Baumann, Juliane, Sachs, Laura, Otto, Oliver, Schoen, Ingmar, Nestler, Peter, Zaninetti, Carlo, Kenny, Martin, Kranz, Ruth, von Eysmondt, Hendrik, Rodriguez, Johanna, Schäffer, Tilman E., Nagy, Zoltan, Greinacher, Andreas, Palankar, Raghavendra, Bender, Markus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9116608/
https://www.ncbi.nlm.nih.gov/pubmed/35584211
http://dx.doi.org/10.1126/sciadv.abn2627

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9116608/
https://www.ncbi.nlm.nih.gov/pubmed/35584211
http://dx.doi.org/10.1126/sciadv.abn2627

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