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Developing predictive hybridization models for phosphorothioate oligonucleotides using high-resolution melting
The ability to predict nucleic acid hybridization energies has been greatly enabling for many applications, but predictive models require painstaking experimentation, which may limit expansion to non-natural nucleic acid analogues and chemistries. We have assessed the utility of dye-based, high-reso...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9116672/ https://www.ncbi.nlm.nih.gov/pubmed/35584176 http://dx.doi.org/10.1371/journal.pone.0268575 |