Synaptic Integration in CA1 Pyramidal Neurons Is Intact despite Deficits in GABAergic Transmission in the Scn1a Haploinsufficiency Mouse Model of Dravet Syndrome

Mutations of SCN1A, which encodes the voltage-gated sodium channel Na(v)1.1, can cause epilepsy disorders such as Dravet syndrome (DS) that are comorbid with wide-ranging neurologic dysfunction. Many studies suggest that Na(v)1.1 haploinsufficiency causes forebrain GABAergic interneuron hypoexcitabi...

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Detalles Bibliográficos
Autores principales: Chancey, Jessica Hotard, Howard, MacKenzie Allen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2022
Materias:
Research Article: New Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9116933/
https://www.ncbi.nlm.nih.gov/pubmed/35523580
http://dx.doi.org/10.1523/ENEURO.0080-22.2022

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9116933/
https://www.ncbi.nlm.nih.gov/pubmed/35523580
http://dx.doi.org/10.1523/ENEURO.0080-22.2022

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