Cargando…

Synaptic Integration in CA1 Pyramidal Neurons Is Intact despite Deficits in GABAergic Transmission in the Scn1a Haploinsufficiency Mouse Model of Dravet Syndrome

Mutations of SCN1A, which encodes the voltage-gated sodium channel Na(v)1.1, can cause epilepsy disorders such as Dravet syndrome (DS) that are comorbid with wide-ranging neurologic dysfunction. Many studies suggest that Na(v)1.1 haploinsufficiency causes forebrain GABAergic interneuron hypoexcitabi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chancey, Jessica Hotard, Howard, MacKenzie Allen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Society for Neuroscience 2022
Materias:	Research Article: New Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9116933/ https://www.ncbi.nlm.nih.gov/pubmed/35523580 http://dx.doi.org/10.1523/ENEURO.0080-22.2022

Ejemplares similares

Delayed maturation of GABAergic signaling in the Scn1a and Scn1b mouse models of Dravet Syndrome
por: Yuan, Yukun, et al.
Publicado: (2019)

Behavioral Comorbidities and Drug Treatments in a Zebrafish scn1lab Model of Dravet Syndrome
por: Grone, Brian P., et al.
Publicado: (2017)

Stiripentol for Dravet syndrome
Publicado: (2020)

Efficacy of Stiripentol in Dravet Syndrome with or without SCN1A Mutations
por: Cho, Min Jung, et al.
Publicado: (2018)

Dravet syndrome: a new causative SCN1A mutation?
por: Poryo, Martin, et al.
Publicado: (2017)

Drug repurposing for Dravet syndrome in scn1Lab (−/−) mutant zebrafish
por: Sourbron, Jo, et al.
Publicado: (2019)

Ictal vocalizations in the Scn1a (+/−) mouse model of Dravet syndrome
por: Anderson, Lyndsey L., et al.
Publicado: (2023)

Inhibitory synaptic transmission is impaired at higher extracellular Ca(2+) concentrations in Scn1a(+/−) mouse model of Dravet syndrome
por: Uchino, Kouya, et al.
Publicado: (2021)

Dravet Syndrome in Lebanon: First Report on Cases with SCN1A Mutations
por: Alame, Saada, et al.
Publicado: (2019)

Augmented Reticular Thalamic Bursting and Seizures in Scn1a-Dravet Syndrome
por: Ritter-Makinson, Stefanie, et al.
Publicado: (2019)

Augmented Reticular Thalamic Bursting and Seizures in Scn1a-Dravet Syndrome
por: Ritter-Makinson, Stefanie, et al.
Publicado: (2019)

TANGO With SCN1A: Can This Molecular Dance Defeat Dravet Syndrome?
por: Wagnon, Jacy L.
Publicado: (2020)

SCN1B and SCN2B gene variants analysis in dravet syndrome patients: Analysis of 22 cases
por: Gong, Jiao-E., et al.
Publicado: (2019)

Identification of SCN1A and PCDH19 Mutations in Chinese Children with Dravet Syndrome
por: Kwong, Anna Ka-Yee, et al.
Publicado: (2012)

Morphometry and network-based atrophy patterns in SCN1A-related Dravet syndrome
por: Lenge, Matteo, et al.
Publicado: (2023)

Cannabidiol for epilepsy (Lennox-Gastaut syndrome, Dravet syndrome)
Publicado: (2020)

SCN1A Gene Mutation and Adaptive Functioning in 18 Vietnamese Children with Dravet Syndrome
por: Do, Thi Thu Hang, et al.
Publicado: (2017)

SCN1A Mutation—Beyond Dravet Syndrome: A Systematic Review and Narrative Synthesis
por: Ding, Jiangwei, et al.
Publicado: (2021)

Scn8a Antisense Oligonucleotide Is Protective in Mouse Models of SCN8A Encephalopathy and Dravet Syndrome
por: Lenk, Guy M., et al.
Publicado: (2020)

Effects of Fluoxetine and Visual Experience on Glutamatergic and GABAergic Synaptic Proteins in Adult Rat Visual Cortex123
por: Beshara, Simon, et al.
Publicado: (2016)

SCN1A Genetic Test for Dravet Syndrome (Severe Myoclonic Epilepsy of Infancy and its Clinical Subtypes) for use in the Diagnosis, Prognosis, Treatment and Management of Dravet Syndrome
por: Stenhouse, Susan A.R., et al.
Publicado: (2013)

Large-Scale Phenotype-Based Antiepileptic Drug Screening in a Zebrafish Model of Dravet Syndrome1,2,3
por: Dinday, Matthew T., et al.
Publicado: (2015)

Altered Glycolysis and Mitochondrial Respiration in a Zebrafish Model of Dravet Syndrome123
por: Kumar, Maneesh G., et al.
Publicado: (2016)

Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet Syndrome treatment
por: Baraban, Scott C., et al.
Publicado: (2013)

Not all SCN1A epileptic encephalopathies are Dravet syndrome: Early profound Thr226Met phenotype
por: Sadleir, Lynette G., et al.
Publicado: (2017)

Multimodal Analysis of SCN1A Missense Variants Improves Interpretation of Clinically Relevant Variants in Dravet Syndrome
por: Gonsales, Marina C., et al.
Publicado: (2019)

Beyond Dravet Syndrome: Characterization of a Novel, More Severe SCN1A-Linked Epileptic Encephalopathy
por: Beck, Veronica C., et al.
Publicado: (2019)

Epilepsy and neuropsychiatric comorbidities in mice carrying a recurrent Dravet syndrome SCN1A missense mutation
por: Ricobaraza, Ana, et al.
Publicado: (2019)

The dose makes the poison—Novel insights into Dravet syndrome and SCN1A regulation through nonproductive splicing
por: Helbig, Ingo, et al.
Publicado: (2021)

Presynaptic HCN channels constrain GABAergic synaptic transmission in pyramidal cells of the medial prefrontal cortex
por: Cai, Wei, et al.
Publicado: (2022)

Differential pH Dynamics in Synaptic Vesicles From Intact Glutamatergic and GABAergic Synapses
por: Herman, Melissa A., et al.
Publicado: (2018)

Enhanced Synaptic Transmission in the Extended Amygdala and Altered Excitability in an Extended Amygdala to Brainstem Circuit in a Dravet Syndrome Mouse Model
por: Yan, Wen Wei, et al.
Publicado: (2021)

Nav1.1 haploinsufficiency in excitatory neurons ameliorates seizure-associated sudden death in a mouse model of Dravet syndrome
por: Ogiwara, Ikuo, et al.
Publicado: (2013)

Autistic behavior in Scn1a(+/−) mice and rescue by enhanced GABAergic transmission
por: Han, Sung, et al.
Publicado: (2012)

Selective Overexpression of Collybistin in Mouse Hippocampal Pyramidal Cells Enhances GABAergic Neurotransmission and Protects against PTZ-Induced Seizures
por: George, Shanu, et al.
Publicado: (2021)

GABAergic Neuron Deficit As An Idiopathic Generalized Epilepsy Mechanism: The Role Of BRD2 Haploinsufficiency In Juvenile Myoclonic Epilepsy
por: Velíšek, Libor, et al.
Publicado: (2011)

Transfer of SCN1A to the brain of adolescent mouse model of Dravet syndrome improves epileptic, motor, and behavioral manifestations
por: Mora-Jimenez, Lucia, et al.
Publicado: (2021)

Dravet Variant SCN1A(A1783V) Impairs Interneuron Firing Predominantly by Altered Channel Activation
por: Layer, Nikolas, et al.
Publicado: (2021)

The Role of Focal Epilepsy Features in Defining SCN1A Mutation-positive Dravet Syndrome as Generalized and Focal Epilepsy
por: Ko, Young Jun, et al.
Publicado: (2021)

Heat-induced seizures, premature mortality, and hyperactivity in a novel Scn1a nonsense model for Dravet syndrome
por: Mavashov, Anat, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_ol6rfe2fdtn1ptv9i95m2un29v