USP14-regulated allostery of the human proteasome by time-resolved cryo-EM

Proteasomal degradation of ubiquitylated proteins is tightly regulated at multiple levels(1–3). A primary regulatory checkpoint is the removal of ubiquitin chains from substrates by the deubiquitylating enzyme ubiquitin-specific protease 14 (USP14), which reversibly binds the proteasome and confers...

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Detalles Bibliográficos
Autores principales: Zhang, Shuwen, Zou, Shitao, Yin, Deyao, Zhao, Lihong, Finley, Daniel, Wu, Zhaolong, Mao, Youdong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9117149/
https://www.ncbi.nlm.nih.gov/pubmed/35477760
http://dx.doi.org/10.1038/s41586-022-04671-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9117149/
https://www.ncbi.nlm.nih.gov/pubmed/35477760
http://dx.doi.org/10.1038/s41586-022-04671-8

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