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USP14-regulated allostery of the human proteasome by time-resolved cryo-EM
Proteasomal degradation of ubiquitylated proteins is tightly regulated at multiple levels(1–3). A primary regulatory checkpoint is the removal of ubiquitin chains from substrates by the deubiquitylating enzyme ubiquitin-specific protease 14 (USP14), which reversibly binds the proteasome and confers...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9117149/ https://www.ncbi.nlm.nih.gov/pubmed/35477760 http://dx.doi.org/10.1038/s41586-022-04671-8 |