Panx1 channels promote both anti- and pro-seizure-like activities in the zebrafish via p2rx7 receptors and ATP signaling

The molecular mechanisms of excitation/inhibition imbalances promoting seizure generation in epilepsy patients are not fully understood. Evidence suggests that Pannexin1 (Panx1), an ATP release channel, modulates the excitability of the brain. In this report, we performed electrophysiological, behav...

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Detalles Bibliográficos
Autores principales: Whyte-Fagundes, Paige, Taskina, Daria, Safarian, Nickie, Zoidl, Christiane, Carlen, Peter L., Donaldson, Logan W., Zoidl, Georg R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9117279/
https://www.ncbi.nlm.nih.gov/pubmed/35585187
http://dx.doi.org/10.1038/s42003-022-03356-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9117279/
https://www.ncbi.nlm.nih.gov/pubmed/35585187
http://dx.doi.org/10.1038/s42003-022-03356-2

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