Programmable deletion, replacement, integration, and inversion of large DNA sequences with twin prime editing

The targeted deletion, replacement, integration, or inversion of genomic sequences could be used to study or treat human genetic diseases, but existing methods typically require double-strand DNA breaks (DSBs) that lead to undesired consequences including uncontrolled indel mixtures and chromosomal...

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Detalles Bibliográficos
Autores principales: Anzalone, Andrew V., Gao, Xin D., Podracky, Christopher J., Nelson, Andrew T., Koblan, Luke W., Raguram, Aditya, Levy, Jonathan M., Mercer, Jaron A. M., Liu, David R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9117393/
https://www.ncbi.nlm.nih.gov/pubmed/34887556
http://dx.doi.org/10.1038/s41587-021-01133-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9117393/
https://www.ncbi.nlm.nih.gov/pubmed/34887556
http://dx.doi.org/10.1038/s41587-021-01133-w

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