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Programmable deletion, replacement, integration, and inversion of large DNA sequences with twin prime editing
The targeted deletion, replacement, integration, or inversion of genomic sequences could be used to study or treat human genetic diseases, but existing methods typically require double-strand DNA breaks (DSBs) that lead to undesired consequences including uncontrolled indel mixtures and chromosomal...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9117393/ https://www.ncbi.nlm.nih.gov/pubmed/34887556 http://dx.doi.org/10.1038/s41587-021-01133-w |