HOXB13 suppresses de novo lipogenesis through HDAC3-mediated epigenetic reprogramming in prostate cancer

HOXB13, a homeodomain transcription factor, critically regulates androgen receptor (AR) activities and androgen-dependent prostate cancer (PCa) growth. However, its functions in AR-independent contexts remain elusive. Here we report HOXB13 interaction with histone deacetylase HDAC3, which is disrupt...

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Detalles Bibliográficos
Autores principales: Lu, Xiaodong, Fong, Ka-wing, Gritsina, Galina, Wang, Fang, Baca, Sylvan C., Brea, Lourdes T., Berchuck, Jacob E., Spisak, Sandor, Ross, Jenny, Morrissey, Colm, Corey, Eva, Chandel, Navdeep S., Catalona, William J., Yang, Ximing, Freedman, Matthew L., Zhao, Jonathan C., Yu, Jindan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9117466/
https://www.ncbi.nlm.nih.gov/pubmed/35468964
http://dx.doi.org/10.1038/s41588-022-01045-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9117466/
https://www.ncbi.nlm.nih.gov/pubmed/35468964
http://dx.doi.org/10.1038/s41588-022-01045-8

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