Intrinsically disordered regions couple the ligand binding and kinase activation of Trk neurotrophin receptors

Receptor tyrosine kinases (RTKs) are key players in development and several diseases. Understanding the molecular mechanism of RTK activation by its ligand could lead to the design of new RTK inhibitors. How the extracellular domain is coupled to the intracellular kinase domain is a matter of debate...

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Detalles Bibliográficos
Autores principales: Kot, Erik F., Franco, María L., Vasilieva, Ekaterina V., Shabalkina, Alexandra V., Arseniev, Alexander S., Goncharuk, Sergey A., Mineev, Konstantin S., Vilar, Marçal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9117555/
https://www.ncbi.nlm.nih.gov/pubmed/35601915
http://dx.doi.org/10.1016/j.isci.2022.104348

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9117555/
https://www.ncbi.nlm.nih.gov/pubmed/35601915
http://dx.doi.org/10.1016/j.isci.2022.104348

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