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Intrinsically disordered regions couple the ligand binding and kinase activation of Trk neurotrophin receptors
Receptor tyrosine kinases (RTKs) are key players in development and several diseases. Understanding the molecular mechanism of RTK activation by its ligand could lead to the design of new RTK inhibitors. How the extracellular domain is coupled to the intracellular kinase domain is a matter of debate...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9117555/ https://www.ncbi.nlm.nih.gov/pubmed/35601915 http://dx.doi.org/10.1016/j.isci.2022.104348 |