Impact of duration of critical illness and level of systemic glucocorticoid availability on tissue-specific glucocorticoid receptor expression and actions: A prospective, observational, cross-sectional human and two translational mouse studies

BACKGROUND: Reduced glucocorticoid-receptor (GR) expression in blood suggested that critically ill patients become glucocorticoid-resistant necessitating stress-doses of glucocorticoids. We hypothesised that critical illness evokes a tissue-specific, time-dependent expression of regulators of GR-act...

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Detalles Bibliográficos
Autores principales: Téblick, Arno, Van Dyck, Lisa, Van Aerde, Nathalie, Van der Perre, Sarah, Pauwels, Lies, Derese, Inge, Debaveye, Yves, Wouters, Pieter J., Vanhorebeek, Ilse, Langouche, Lies, Van den Berghe, Greet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9117556/
https://www.ncbi.nlm.nih.gov/pubmed/35584557
http://dx.doi.org/10.1016/j.ebiom.2022.104057

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9117556/
https://www.ncbi.nlm.nih.gov/pubmed/35584557
http://dx.doi.org/10.1016/j.ebiom.2022.104057

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