Cargando…

Impact of duration of critical illness and level of systemic glucocorticoid availability on tissue-specific glucocorticoid receptor expression and actions: A prospective, observational, cross-sectional human and two translational mouse studies

BACKGROUND: Reduced glucocorticoid-receptor (GR) expression in blood suggested that critically ill patients become glucocorticoid-resistant necessitating stress-doses of glucocorticoids. We hypothesised that critical illness evokes a tissue-specific, time-dependent expression of regulators of GR-act...

Descripción completa

Detalles Bibliográficos
Autores principales:	Téblick, Arno, Van Dyck, Lisa, Van Aerde, Nathalie, Van der Perre, Sarah, Pauwels, Lies, Derese, Inge, Debaveye, Yves, Wouters, Pieter J., Vanhorebeek, Ilse, Langouche, Lies, Van den Berghe, Greet
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9117556/ https://www.ncbi.nlm.nih.gov/pubmed/35584557 http://dx.doi.org/10.1016/j.ebiom.2022.104057

Ejemplares similares

OR26-4 Glucocorticoid Receptor Expression and Signaling During Critical Illness, in Relation to the Duration of Illness and the Systemic Glucocorticoid Availability: A Prospective, Observational, Cross-Sectional Human and a Translational Mouse Study
por: Téblick, Arno, et al.
Publicado: (2022)

The role of pro-opiomelanocortin in the ACTH–cortisol dissociation of sepsis
por: Téblick, Arno, et al.
Publicado: (2021)

OR19-06 Sepsis-Induced Critical Illness in Mice Alters Key Regulators of ACTH Production and Secretion Within the Anterior Pituitary Gland
por: Téblick, Arno, et al.
Publicado: (2020)

DNA methylation alterations in muscle of critically ill patients
por: Van Dyck, Lisa, et al.
Publicado: (2022)

Anterior pituitary function in critical illness
por: Téblick, Arno, et al.
Publicado: (2019)

Impact of Hydrocortisone and of CRH Infusion on the Hypothalamus-Pituitary-Adrenocortical Axis of Septic Male Mice
por: Téblick, Arno, et al.
Publicado: (2021)

ACTH and cortisol responses to CRH in acute, subacute, and prolonged critical illness: a randomized, double-blind, placebo-controlled, crossover cohort study
por: Peeters, Bram, et al.
Publicado: (2018)

SAT-155 Temporal Activation of the Unfolded Protein Response and Concomitant Downregulation of Key Hepatic Transcription Factors in Critical Illness
por: Vankrunkelsven, Wouter, et al.
Publicado: (2019)

RF09 | PSAT88 Pro-opiomelanocortin (POMC), ACTH and Cortisol Responses to Pediatric Cardiac Surgery
por: Téblick, Arno, et al.
Publicado: (2022)

The hypothalamus-pituitary-adrenal axis in sepsis- and hyperinflammation-induced critical illness: Gaps in current knowledge and future translational research directions
por: Van den Berghe, Greet, et al.
Publicado: (2022)

The Hypothalamus-pituitary-adrenocortical Response to Critical Illness: A Concept in Need of Revision
por: Langouche, Lies, et al.
Publicado: (2023)

OR16-4 The Growth Hormone Axis in Relation to Muscle Weakness in the ICU: Effect of Early Macronutrient Deficit
por: Van Dyck, Lisa, et al.
Publicado: (2019)

Obesity attenuates inflammation, protein catabolism, dyslipidaemia, and muscle weakness during sepsis, independent of leptin
por: Vankrunkelsven, Wouter, et al.
Publicado: (2022)

THU155 Aberrant DNA Methylation Within Genes Of The HPA-axis Two Years After Paediatric Critical Illness, Role Of Glucocorticoid Treatment And Association With Impaired Physical And Neurocognitive Development.
por: Coppens, Gregoire, et al.
Publicado: (2023)

Adrenocortical function during prolonged critical illness and beyond: a prospective observational study
por: Peeters, Bram, et al.
Publicado: (2018)

OR20-6 Ketones and Sepsis-Induced Muscle Weakness: Signal or Fuel for Protection?
por: Weckx, Ruben, et al.
Publicado: (2019)

Efficacy and safety of ketone ester infusion to prevent muscle weakness in a mouse model of sepsis-induced critical illness
por: Weckx, Ruben, et al.
Publicado: (2022)

OR17-1 Changes in the Hypothalamic-Pituitary-Adrenal Axis during Pediatric Critical Illness
por: Jacobs, An, et al.
Publicado: (2019)

Skeletal Muscle Myokine Expression in Critical Illness, Association With Outcome and Impact of Therapeutic Interventions
por: Vanhorebeek, Ilse, et al.
Publicado: (2023)

Persisting neuroendocrine abnormalities and their association with physical impairment 5 years after critical illness
por: Vanhorebeek, Ilse, et al.
Publicado: (2021)

Proliferation and differentiation of adipose tissue in prolonged lean and obese critically ill patients
por: Goossens, Chloë, et al.
Publicado: (2017)

The Role of Autophagy in Critical Illness-induced Liver Damage
por: Thiessen, Steven E., et al.
Publicado: (2017)

The soluble mannose receptor (sMR/sCD206) in critically ill patients with invasive fungal infections, bacterial infections or non-infectious inflammation: a secondary analysis of the EPaNIC RCT
por: De Vlieger, Greet, et al.
Publicado: (2019)

The association of hypoglycemia with outcome of critically ill children in relation to nutritional and blood glucose control strategies
por: Gunst, Jan, et al.
Publicado: (2023)

Development of muscle weakness in a mouse model of critical illness: does fibroblast growth factor 21 play a role?
por: Vankrunkelsven, Wouter, et al.
Publicado: (2023)

Altered cholesterol homeostasis in critical illness-induced muscle weakness: effect of exogenous 3-hydroxybutyrate
por: Goossens, Chloë, et al.
Publicado: (2021)

On the Role of Illness Duration and Nutrient Restriction in Cholestatic Alterations that Occur During Critical Illness
por: Jenniskens, Marc, et al.
Publicado: (2018)

Nonthyroidal Illness Syndrome Across the Ages
por: Langouche, Lies, et al.
Publicado: (2019)

Identification of the toxic threshold of 3-hydroxybutyrate-sodium supplementation in septic mice
por: Weckx, Ruben, et al.
Publicado: (2021)

The clinical potential of GDF15 as a “ready-to-feed indicator” for critically ill adults
por: Van Dyck, Lisa, et al.
Publicado: (2020)

Towards a fasting-mimicking diet for critically ill patients: the pilot randomized crossover ICU-FM-1 study
por: Van Dyck, Lisa, et al.
Publicado: (2020)

Impact of withholding early parenteral nutrition in adult critically ill patients on ketogenesis in relation to outcome
por: De Bruyn, Astrid, et al.
Publicado: (2021)

Adipose tissue protects against sepsis-induced muscle weakness in mice: from lipolysis to ketones
por: Goossens, Chloë, et al.
Publicado: (2019)

Hyperglycemia and insulin resistance in COVID-19 versus non-COVID critical illness: Are they really different?
por: Langouche, Lies, et al.
Publicado: (2021)

Dynamics and prognostic value of the hypothalamus–pituitary–adrenal axis responses to pediatric critical illness and association with corticosteroid treatment: a prospective observational study
por: Jacobs, An, et al.
Publicado: (2019)

Adiponectin, retinol-binding protein 4, and leptin in protracted critical illness of pulmonary origin
por: Langouche, Lies, et al.
Publicado: (2009)

Time course of altered DNA methylation evoked by critical illness and by early administration of parenteral nutrition in the paediatric ICU
por: Verlinden, Ines, et al.
Publicado: (2020)

SUN-548 Ketone Bodies in Critical Illness Alter Cholesterol Synthesis in Skeletal Muscle, Interlinked with Protection Against Weakness
por: Goossens, Chloë, et al.
Publicado: (2020)

Impact of tight glucose control on circulating 3-hydroxybutyrate in critically ill patients
por: Gunst, Jan, et al.
Publicado: (2021)

Premorbid obesity, but not nutrition, prevents critical illness‐induced muscle wasting and weakness
por: Goossens, Chloë, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_mu5d7fk8l7jsqfsk59thh34nba