Unexpected Dynamic Binding May Rescue the Binding Affinity of Rivaroxaban in a Mutant of Coagulation Factor X

A novel coagulation factor X (FX) Tyr319Cys mutation (Y99C as chymotrypsin numbering) was identified in a patient with severe bleeding. Unlike the earlier reported Y99A mutant, this mutant can bind and cleave its specific chromogenetic substrate at a normal level, suggesting an intact binding pocket...

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Detalles Bibliográficos
Autores principales: Zhang, Zhi-Li, Chen, Changming, Qu, Si-Ying, Ding, Qiulan, Xu, Qin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9117642/
https://www.ncbi.nlm.nih.gov/pubmed/35601826
http://dx.doi.org/10.3389/fmolb.2022.877170

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9117642/
https://www.ncbi.nlm.nih.gov/pubmed/35601826
http://dx.doi.org/10.3389/fmolb.2022.877170

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