Structural basis for inhibition of the Cation-chloride cotransporter NKCC1 by the diuretic drug bumetanide

Cation-chloride cotransporters (CCCs) NKCC1 and NKCC2 catalyze electroneutral symport of 1 Na(+), 1 K(+), and 2 Cl(−) across cell membranes. NKCC1 mediates trans-epithelial Cl(−) secretion and regulates excitability of some neurons and NKCC2 is critical to renal salt reabsorption. Both transporters...

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Detalles Bibliográficos
Autores principales: Zhao, Yongxiang, Roy, Kasturi, Vidossich, Pietro, Cancedda, Laura, De Vivo, Marco, Forbush, Biff, Cao, Erhu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9117670/
https://www.ncbi.nlm.nih.gov/pubmed/35585053
http://dx.doi.org/10.1038/s41467-022-30407-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9117670/
https://www.ncbi.nlm.nih.gov/pubmed/35585053
http://dx.doi.org/10.1038/s41467-022-30407-3

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