BAP1 phosphorylation-mediated Sp1 stabilization plays a critical role in cathepsin K inhibition-induced C-terminal p53-dependent Bax upregulation

Cathepsin K inhibitor (odanacatib; ODN) and cathepsin K knockdown (siRNA) enhance oxaliplatin-induced apoptosis through p53-dependent Bax upregulation. However, its underlying mechanisms remain unclear. In this study, we elucidated the mechanism behind enhancement of oxaliplatin-induced apoptosis by...

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Detalles Bibliográficos
Autores principales: Seo, Seung Un, Woo, Seon Min, Lee, Seul Gi, Kim, Min Yeong, Lee, Hyun Shik, Choi, Yung Hyun, Kim, Sang Hyun, Chang, Young-Chae, Min, Kyoung-jin, Kwon, Taeg Kyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9117696/
https://www.ncbi.nlm.nih.gov/pubmed/35584569
http://dx.doi.org/10.1016/j.redox.2022.102336

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9117696/
https://www.ncbi.nlm.nih.gov/pubmed/35584569
http://dx.doi.org/10.1016/j.redox.2022.102336

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