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BAP1 phosphorylation-mediated Sp1 stabilization plays a critical role in cathepsin K inhibition-induced C-terminal p53-dependent Bax upregulation

Cathepsin K inhibitor (odanacatib; ODN) and cathepsin K knockdown (siRNA) enhance oxaliplatin-induced apoptosis through p53-dependent Bax upregulation. However, its underlying mechanisms remain unclear. In this study, we elucidated the mechanism behind enhancement of oxaliplatin-induced apoptosis by...

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Detalles Bibliográficos
Autores principales:	Seo, Seung Un, Woo, Seon Min, Lee, Seul Gi, Kim, Min Yeong, Lee, Hyun Shik, Choi, Yung Hyun, Kim, Sang Hyun, Chang, Young-Chae, Min, Kyoung-jin, Kwon, Taeg Kyu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9117696/ https://www.ncbi.nlm.nih.gov/pubmed/35584569 http://dx.doi.org/10.1016/j.redox.2022.102336

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