Inhibition of Spleen Tyrosine Kinase Restores Glucocorticoid Sensitivity to Improve Steroid-Resistant Asthma

Background: Regulation or restoration of therapeutic sensitivity to glucocorticoids is important in patients with steroid-resistant asthma. Spleen tyrosine kinase (Syk) is activated at high levels in asthma patients and mouse models, and small-molecule Syk inhibitors such as R406 show potent anti-in...

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Detalles Bibliográficos
Autores principales: Liu, Qian, Hua, Lijuan, Bao, Chen, Kong, Luxia, Hu, Jiannan, Liu, Chao, Li, Ziling, Xu, Shuyun, Liu, Xiansheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9117698/
https://www.ncbi.nlm.nih.gov/pubmed/35600871
http://dx.doi.org/10.3389/fphar.2022.885053

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9117698/
https://www.ncbi.nlm.nih.gov/pubmed/35600871
http://dx.doi.org/10.3389/fphar.2022.885053

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