Poly(pseudo)rotaxanes formed by mixed micelles and α-cyclodextrin enhance terbinafine nail permeation to deeper layers

This work aimed to develop water-based formulations for onychomycosis topical treatment using micelles of small pegylated surfactants associated with α-cyclodextrin (αCD) to deliver terbinafine to the nail. Kolliphor® RH40 (RH40) and Gelucire® 48/16 (GEL) single and mixed micelles (RH40:GEL 1:1) wer...

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Detalles Bibliográficos
Autores principales: Krawczyk-Santos, Anna Paula, Marreto, Ricardo Neves, Concheiro, Angel, Alvarez-Lorenzo, Carmen, Taveira, Stephânia Fleury
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9117884/
https://www.ncbi.nlm.nih.gov/pubmed/35602759
http://dx.doi.org/10.1016/j.ijpx.2022.100118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9117884/
https://www.ncbi.nlm.nih.gov/pubmed/35602759
http://dx.doi.org/10.1016/j.ijpx.2022.100118

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