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Poly(pseudo)rotaxanes formed by mixed micelles and α-cyclodextrin enhance terbinafine nail permeation to deeper layers
This work aimed to develop water-based formulations for onychomycosis topical treatment using micelles of small pegylated surfactants associated with α-cyclodextrin (αCD) to deliver terbinafine to the nail. Kolliphor® RH40 (RH40) and Gelucire® 48/16 (GEL) single and mixed micelles (RH40:GEL 1:1) wer...
Autores principales: | Krawczyk-Santos, Anna Paula, Marreto, Ricardo Neves, Concheiro, Angel, Alvarez-Lorenzo, Carmen, Taveira, Stephânia Fleury |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9117884/ https://www.ncbi.nlm.nih.gov/pubmed/35602759 http://dx.doi.org/10.1016/j.ijpx.2022.100118 |
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