Ammonia induces amyloidogenesis in astrocytes by promoting amyloid precursor protein translocation into the endoplasmic reticulum

Hyperammonemia is known to cause various neurological dysfunctions such as seizures and cognitive impairment. Several studies have suggested that hyperammonemia may also be linked to the development of Alzheimer’s disease (AD). However, the direct evidence for a role of ammonia in the pathophysiolog...

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Detalles Bibliográficos
Autores principales: Komatsu, Ayaka, Iida, Izumi, Nasu, Yusuke, Ito, Genki, Harada, Fumiko, Kishikawa, Sari, Moss, Stephen J., Maeda, Takeyasu, Terunuma, Miho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9117890/
https://www.ncbi.nlm.nih.gov/pubmed/35427648
http://dx.doi.org/10.1016/j.jbc.2022.101933

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9117890/
https://www.ncbi.nlm.nih.gov/pubmed/35427648
http://dx.doi.org/10.1016/j.jbc.2022.101933

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