Computational epitope binning reveals functional equivalence of sequence-divergent paratopes

The therapeutic efficacy of a protein binder largely depends on two factors: its binding site and its binding affinity. Advances in in vitro library display screening and next-generation sequencing have enabled accelerated development of strong binders, yet identifying their binding sites still rema...

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Detalles Bibliográficos
Autores principales: Mahita, Jarjapu, Kim, Dong-Gun, Son, Sumin, Choi, Yoonjoo, Kim, Hak-Sung, Bailey-Kellogg, Chris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9118127/
https://www.ncbi.nlm.nih.gov/pubmed/35615020
http://dx.doi.org/10.1016/j.csbj.2022.04.036

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9118127/
https://www.ncbi.nlm.nih.gov/pubmed/35615020
http://dx.doi.org/10.1016/j.csbj.2022.04.036

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