(1)H NMR Signals from Urine Excreted Protein Are a Source of Bias in Probabilistic Quotient Normalization

[Image: see text] Normalization to account for variation in urinary dilution is crucial for interpretation of urine metabolic profiles. Probabilistic quotient normalization (PQN) is used routinely in metabolomics but is sensitive to systematic variation shared across a large proportion of the spectr...

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Detalles Bibliográficos
Autores principales: Correia, Gonçalo D. S., Takis, Panteleimon G., Sands, Caroline J., Kowalka, Anna M., Tan, Tricia, Turtle, Lance, Ho, Antonia, Semple, Malcolm G., Openshaw, Peter J. M., Baillie, J. Kenneth, Takáts, Zoltán, Lewis, Matthew R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9118196/
https://www.ncbi.nlm.nih.gov/pubmed/35503092
http://dx.doi.org/10.1021/acs.analchem.2c00466

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9118196/
https://www.ncbi.nlm.nih.gov/pubmed/35503092
http://dx.doi.org/10.1021/acs.analchem.2c00466

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