Ion-Based Proteome-Integrated Solubility Alteration Assays for Systemwide Profiling of Protein–Molecule Interactions

[Image: see text] Unbiased drug target engagement deconvolution and mechanism of action elucidation are major challenges in drug development. Modification-free target engagement methods, such as thermal proteome profiling, have gained increasing popularity in the last several years. However, these m...

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Detalles Bibliográficos
Autores principales: Beusch, Christian M., Sabatier, Pierre, Zubarev, Roman A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9118197/
https://www.ncbi.nlm.nih.gov/pubmed/35506705
http://dx.doi.org/10.1021/acs.analchem.2c00391

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9118197/
https://www.ncbi.nlm.nih.gov/pubmed/35506705
http://dx.doi.org/10.1021/acs.analchem.2c00391

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