A tractable covalent linker strategy for the production of immunogenic antigen-TLR7/8L bioconjugates

Despite the ease of production and improved safety profiles of recombinant vaccines, the inherently low immunogenicity of unadjuvanted proteins remains an impediment to their widespread adoption. The covalent tethering of TLR agonists to antigenic proteins offers a unique approach to co-deliver both...

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Detalles Bibliográficos
Autores principales: Massena, C. J., Lathrop, S. K., Davison, C. J., Schoener, R., Bazin, H. G., Evans, J. T., Burkhart, D. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9118693/
https://www.ncbi.nlm.nih.gov/pubmed/33977971
http://dx.doi.org/10.1039/d1cc00795e

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9118693/
https://www.ncbi.nlm.nih.gov/pubmed/33977971
http://dx.doi.org/10.1039/d1cc00795e

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