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A tractable covalent linker strategy for the production of immunogenic antigen-TLR7/8L bioconjugates
Despite the ease of production and improved safety profiles of recombinant vaccines, the inherently low immunogenicity of unadjuvanted proteins remains an impediment to their widespread adoption. The covalent tethering of TLR agonists to antigenic proteins offers a unique approach to co-deliver both...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9118693/ https://www.ncbi.nlm.nih.gov/pubmed/33977971 http://dx.doi.org/10.1039/d1cc00795e |