Structure-guided mutagenesis of a mucin-selective metalloprotease from Akkermansia muciniphila alters substrate preferences

Akkermansia muciniphila, a mucin-degrading microbe found in the human gut, is often associated with positive health outcomes. The abundance of A. muciniphila is modulated by the presence and accessibility of nutrients, which can be derived from diet or host glycoproteins. In particular, the ability...

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Detalles Bibliográficos
Autores principales: Shon, D. Judy, Fernandez, Daniel, Riley, Nicholas M., Ferracane, Michael J., Bertozzi, Carolyn R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9118916/
https://www.ncbi.nlm.nih.gov/pubmed/35405095
http://dx.doi.org/10.1016/j.jbc.2022.101917

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9118916/
https://www.ncbi.nlm.nih.gov/pubmed/35405095
http://dx.doi.org/10.1016/j.jbc.2022.101917

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