Pilot study evaluating everolimus molecular mechanisms in tuberous sclerosis complex and focal cortical dysplasia

BACKGROUND: Tuberous sclerosis complex (TSC) and some focal cortical dysplasias (FCDs) are associated with dysfunctional mTOR signaling, resulting in increased cell growth and ribosomal S6 protein phosphorylation (phospho-S6). mTOR inhibitors can reduce TSC tumor growth and seizure frequency, and pr...

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Detalles Bibliográficos
Autores principales: Leitner, Dominique F., Kanshin, Evgeny, Askenazi, Manor, Siu, Yik, Friedman, Daniel, Devore, Sasha, Jones, Drew, Ueberheide, Beatrix, Wisniewski, Thomas, Devinsky, Orrin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9119437/
https://www.ncbi.nlm.nih.gov/pubmed/35587487
http://dx.doi.org/10.1371/journal.pone.0268597

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9119437/
https://www.ncbi.nlm.nih.gov/pubmed/35587487
http://dx.doi.org/10.1371/journal.pone.0268597

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