Cargando…

Pilot study evaluating everolimus molecular mechanisms in tuberous sclerosis complex and focal cortical dysplasia

BACKGROUND: Tuberous sclerosis complex (TSC) and some focal cortical dysplasias (FCDs) are associated with dysfunctional mTOR signaling, resulting in increased cell growth and ribosomal S6 protein phosphorylation (phospho-S6). mTOR inhibitors can reduce TSC tumor growth and seizure frequency, and pr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Leitner, Dominique F., Kanshin, Evgeny, Askenazi, Manor, Siu, Yik, Friedman, Daniel, Devore, Sasha, Jones, Drew, Ueberheide, Beatrix, Wisniewski, Thomas, Devinsky, Orrin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9119437/ https://www.ncbi.nlm.nih.gov/pubmed/35587487 http://dx.doi.org/10.1371/journal.pone.0268597

Ejemplares similares

Raphe and ventrolateral medulla proteomics in epilepsy and sudden unexpected death in epilepsy
por: Leitner, Dominique F, et al.
Publicado: (2022)

Localized proteomic differences in the choroid plexus of Alzheimer's disease and epilepsy patients
por: Leitner, Dominique F., et al.
Publicado: (2023)

Proteomic differences in hippocampus and cortex of sudden unexplained death in childhood
por: Leitner, Dominique F., et al.
Publicado: (2022)

Proteomics and Transcriptomics of the Hippocampus and Cortex in SUDEP and High-Risk SUDEP Patients
por: Leitner, Dominique F., et al.
Publicado: (2021)

Compilation of reported protein changes in the brain in Alzheimer’s disease
por: Askenazi, Manor, et al.
Publicado: (2023)

Neuropathology in the North American sudden unexpected death in epilepsy registry
por: Leitner, Dominique F, et al.
Publicado: (2021)

Specific Features of Focal Cortical Dysplasia in Tuberous Sclerosis Complex
por: Bychkova, Ekaterina, et al.
Publicado: (2023)

Mitochondrial STAT3 regulates antioxidant gene expression through complex I‐derived NAD in triple negative breast cancer
por: Lahiri, Tanaya, et al.
Publicado: (2021)

Cell wall proteomics in live Mycobacterium tuberculosis uncovers exposure of ESX substrates to the periplasm
por: Jaisinghani, Neetika, et al.
Publicado: (2023)

Genetic generalized and focal epilepsy prevalence in the North American SUDEP Registry
por: Verducci, Chloe, et al.
Publicado: (2020)

The amyloid plaque proteome in early onset Alzheimer’s disease and Down syndrome
por: Drummond, Eleanor, et al.
Publicado: (2022)

Cellular antiseizure mechanisms of everolimus in pediatric tuberous sclerosis complex, cortical dysplasia, and non–mTOR‐mediated etiologies
por: Cepeda, Carlos, et al.
Publicado: (2018)

Impaired oligodendroglial turnover is associated with myelin pathology in focal cortical dysplasia and tuberous sclerosis complex
por: Scholl, Theresa, et al.
Publicado: (2017)

The epileptogenic zone in children with tuberous sclerosis complex is characterized by prominent features of focal cortical dysplasia
por: Hulshof, Hanna M., et al.
Publicado: (2021)

Commentary on “The epileptogenic zone in children with tuberous sclerosis complex is characterized by prominent features of focal cortical dysplasia”
por: Wong, Michael
Publicado: (2022)

Downregulation of CD47 and CD200 in patients with focal cortical dysplasia type IIb and tuberous sclerosis complex
por: Sun, Fei-Ji, et al.
Publicado: (2016)

Early manifestations of renal disease in patients with tuberous sclerosis complex
por: Malaga-Dieguez, Laura, et al.
Publicado: (2017)

Long-term priors influence visual perception through recruitment of long-range feedback
por: Hardstone, Richard, et al.
Publicado: (2021)

Increased expression of complement components in tuberous sclerosis complex and focal cortical dysplasia type 2B brain lesions
por: Gruber, Victoria‐Elisabeth, et al.
Publicado: (2021)

Everolimus for treatment of tuberous sclerosis complex‐associated neuropsychiatric disorders
por: Krueger, Darcy A., et al.
Publicado: (2017)

Focal cortical dysplasia – review
por: Kabat, Joanna, et al.
Publicado: (2012)

MRI of focal cortical dysplasia
por: Urbach, Horst, et al.
Publicado: (2021)

Moment-by-moment tracking of naturalistic learning and its underlying hippocampo-cortical interactions
por: Michelmann, Sebastian, et al.
Publicado: (2021)

Upregulation of the pathogenic transcription factor SPI1/PU.1 in tuberous sclerosis complex and focal cortical dysplasia by oxidative stress
por: Zimmer, Till S., et al.
Publicado: (2021)

The REEP5/TRAM1 complex binds SARS-CoV-2 NSP3 and promotes virus replication
por: Li, Jie, et al.
Publicado: (2023)

Adverse Events of Everolimus in Patients with Tuberous Sclerosis Complex Treated for Renal Angiomyolipoma/Subependymal Giant Cell Astrocytoma
por: Gau, Shuo-Yan, et al.
Publicado: (2023)

Fibrous Plaque of the Eyelid in a Patient with Tuberous Sclerosis Responding to Everolimus
por: Park, Sung-Min, et al.
Publicado: (2018)

Everolimus dosing recommendations for tuberous sclerosis complex–associated refractory seizures
por: Franz, David N., et al.
Publicado: (2018)

Everolimus induced organizing pneumonia in a patient with tuberous sclerosis complex
por: Lanfranco, Julio, et al.
Publicado: (2021)

Effect of everolimus on multifocal micronodular pneumocyte hyperplasia in tuberous sclerosis complex
por: Daccord, Cécile, et al.
Publicado: (2020)

Focal Cortical Dysplasia and Epilepsy Surgery
por: Lee, Sang Kun, et al.
Publicado: (2013)

Focal cortical dysplasia type 1
por: Coras, Roland, et al.
Publicado: (2021)

Focal Cortical Dysplasia with hippocampal sclerosis
por: Jadav, Devendra, et al.
Publicado: (2023)

Downregulated formyl peptide receptor 2 expression in the epileptogenic foci of patients with focal cortical dysplasia type IIb and tuberous sclerosis complex
por: Huang, Kaixuan, et al.
Publicado: (2022)

Proteomic analysis of neurons microdissected from formalin-fixed, paraffin-embedded Alzheimer’s disease brain tissue
por: Drummond, Eleanor S, et al.
Publicado: (2015)

Identification of Specific Circular RNA Expression Patterns and MicroRNA Interaction Networks in Mesial Temporal Lobe Epilepsy
por: Gray, Lachlan G., et al.
Publicado: (2020)

SUDEP in patients with epilepsy and nonepileptic seizures
por: Verducci, Chloe, et al.
Publicado: (2019)

Everolimus and intensive behavioral therapy in an adolescent with tuberous sclerosis complex and severe behavior()()()
por: Gipson, Tanjala T., et al.
Publicado: (2013)

Erratum: Fibrous Plaque of the Eyelid in a Patient with Tuberous Sclerosis Responding to Everolimus
por: Park, Sung-Min, et al.
Publicado: (2018)

Effect and Complications of Everolimus Use for Giant Cardiac Rhabdomyomas with Neonatal Tuberous Sclerosis
por: Shibata, Yuka, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_t6hee3s2lb8uebkgubceo74hti