Nano-hydroxyapatite improves intestinal absorption of acetazolamide (BCS Class IV drug)–but how?

We earlier reported that coating poorly water-soluble drugs with nano-hydroxyapatite (nano-HAP) improves bioavailability after oral administration. In the present study, we coated BCS Class IV drug acetazolamide (AZ) with nano-HAP (AZ/HAP formulation), and investigated its bioavailability and nano-H...

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Detalles Bibliográficos
Autores principales: Kaneko, Kenichi, Miyasaka, Ryosuke, Hayman, Roslyn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9119549/
https://www.ncbi.nlm.nih.gov/pubmed/35588130
http://dx.doi.org/10.1371/journal.pone.0268067

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9119549/
https://www.ncbi.nlm.nih.gov/pubmed/35588130
http://dx.doi.org/10.1371/journal.pone.0268067

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