Inflammatory response in hematopoietic stem and progenitor cells triggered by activating SHP2 mutations evokes blood defects

Gain-of-function mutations in the protein-tyrosine phosphatase SHP2 are the most frequently occurring mutations in sporadic juvenile myelomonocytic leukemia (JMML) and JMML-like myeloproliferative neoplasm (MPN) associated with Noonan syndrome (NS). Hematopoietic stem and progenitor cells (HSPCs) ar...

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Detalles Bibliográficos
Autores principales: Solman, Maja, Blokzijl-Franke, Sasja, Piques, Florian, Yan, Chuan, Yang, Qiqi, Strullu, Marion, Kamel, Sarah M, Ak, Pakize, Bakkers, Jeroen, Langenau, David M, Cavé, Hélène, den Hertog, Jeroen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9119675/
https://www.ncbi.nlm.nih.gov/pubmed/35535491
http://dx.doi.org/10.7554/eLife.73040

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9119675/
https://www.ncbi.nlm.nih.gov/pubmed/35535491
http://dx.doi.org/10.7554/eLife.73040

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