Inhibition mechanism of the chloride channel TMEM16A by the pore blocker 1PBC

TMEM16A, a calcium-activated chloride channel involved in multiple cellular processes, is a proposed target for diseases such as hypertension, asthma, and cystic fibrosis. Despite these therapeutic promises, its pharmacology remains poorly understood. Here, we present a cryo-EM structure of TMEM16A...

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Detalles Bibliográficos
Autores principales: Lam, Andy K. M., Rutz, Sonja, Dutzler, Raimund
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9120017/
https://www.ncbi.nlm.nih.gov/pubmed/35589730
http://dx.doi.org/10.1038/s41467-022-30479-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9120017/
https://www.ncbi.nlm.nih.gov/pubmed/35589730
http://dx.doi.org/10.1038/s41467-022-30479-1

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