The lysosomal V-ATPase a3 subunit is involved in localization of Mon1-Ccz1, the GEF for Rab7, to secretory lysosomes in osteoclasts

We have shown previously that the lysosomal a3 isoform of the a subunit of vacuolar-type ATPase (V-ATPase) interacts with inactive (GDP-bound form) Rab7, a small GTPase that regulates late endosome/lysosome trafficking, and that a3 recruits Rab7 to secretory lysosomes in mouse osteoclasts. This is e...

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Detalles Bibliográficos
Autores principales: Matsumoto, Naomi, Sekiya, Mizuki, Sun-Wada, Ge-Hong, Wada, Yoh, Nakanishi-Matsui, Mayumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9120031/
https://www.ncbi.nlm.nih.gov/pubmed/35589873
http://dx.doi.org/10.1038/s41598-022-12397-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9120031/
https://www.ncbi.nlm.nih.gov/pubmed/35589873
http://dx.doi.org/10.1038/s41598-022-12397-w

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