TBK1 haploinsufficiency results in changes in the K63-ubiquitination profiles in brain and fibroblasts from affected and presymptomatic mutation carriers

BACKGROUND: Frontotemporal dementia (FTD) is a neurodegenerative disease, resulting in progressive problems in language and/or behaviour and is often diagnosed before 65 years of age. Ubiquitin positive protein aggregates in the brain are among the key pathologic hallmarks of frontotemporal lobar de...

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Detalles Bibliográficos
Autores principales: Khoshnood, Behzad, Ullgren, Abbe, Laffita-Mesa, Jose, Öijerstedt, Linn, Patra, Kalicharan, Nennesmo, Inger, Graff, Caroline
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Original Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9120096/
https://www.ncbi.nlm.nih.gov/pubmed/34800171
http://dx.doi.org/10.1007/s00415-021-10887-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9120096/
https://www.ncbi.nlm.nih.gov/pubmed/34800171
http://dx.doi.org/10.1007/s00415-021-10887-x

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