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Regulator of G protein signaling 2 inhibits Gα(q)-dependent uveal melanoma cell growth
Activating mutations in Gα(q/11) are a major driver of uveal melanoma (UM), the most common intraocular cancer in adults. While progress has recently been made in targeting Gα(q/11) for UM therapy, the crucial role for these proteins in normal physiology and their high structural similarity with man...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9120238/ https://www.ncbi.nlm.nih.gov/pubmed/35452684 http://dx.doi.org/10.1016/j.jbc.2022.101955 |