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Regulator of G protein signaling 2 inhibits Gα(q)-dependent uveal melanoma cell growth

Activating mutations in Gα(q/11) are a major driver of uveal melanoma (UM), the most common intraocular cancer in adults. While progress has recently been made in targeting Gα(q/11) for UM therapy, the crucial role for these proteins in normal physiology and their high structural similarity with man...

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Detalles Bibliográficos
Autores principales:	Zhang, Qian, Haak, Andrew J., Sjögren, Benita
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9120238/ https://www.ncbi.nlm.nih.gov/pubmed/35452684 http://dx.doi.org/10.1016/j.jbc.2022.101955

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