Braf mutation induces rapid neoplastic transformation in the aged and aberrantly methylated intestinal epithelium

OBJECTIVE: Sessile serrated lesions (SSLs) are common across the age spectrum, but the BRAF mutant cancers arising occur predominantly in the elderly. Aberrant DNA methylation is uncommon in SSL from young patients. Here, we interrogate the role of ageing and DNA methylation in SSL initiation and pr...

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Detalles Bibliográficos
Autores principales: Fennell, Lochlan, Kane, Alexandra, Liu, Cheng, McKeone, Diane, Hartel, Gunter, Su, Chang, Bond, Catherine, Bettington, Mark, Leggett, Barbara, Whitehall, Vicki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Colon
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9120393/
https://www.ncbi.nlm.nih.gov/pubmed/34230216
http://dx.doi.org/10.1136/gutjnl-2020-322166

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9120393/
https://www.ncbi.nlm.nih.gov/pubmed/34230216
http://dx.doi.org/10.1136/gutjnl-2020-322166

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