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Structural mechanism of TRPV3 channel inhibition by the anesthetic dyclonine

Skin diseases are common human illnesses that occur in all cultures, at all ages, and affect between 30% and 70% of individuals globally. TRPV3 is a cation-permeable TRP channel predominantly expressed in skin keratinocytes, implicated in cutaneous sensation and associated with numerous skin disease...

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Detalles Bibliográficos
Autores principales: Neuberger, Arthur, Nadezhdin, Kirill D., Sobolevsky, Alexander I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9120478/
https://www.ncbi.nlm.nih.gov/pubmed/35589741
http://dx.doi.org/10.1038/s41467-022-30537-8