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Multiplex base- and prime-editing with drive-and-process CRISPR arrays
Current base- and prime-editing technologies lack efficient strategies to edit multiple genomic loci simultaneously, limiting their applications in complex genomics and polygenic diseases. Here, we describe drive-and-process (DAP) CRISPR array architectures for multiplex base-editing (MBE) and multi...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9120480/ https://www.ncbi.nlm.nih.gov/pubmed/35589728 http://dx.doi.org/10.1038/s41467-022-30514-1 |