TIN2 deficiency leads to ALT-associated phenotypes and differentiation defects in embryonic stem cells

Telomere integrity is critical for embryonic development, and core telomere-binding proteins, such as TIN2, are key to maintaining telomere stability. Here, we report that homozygous Tin2(S341X) resulted in embryonic lethality in mice and reduced expression of Tin2 in the derived mouse embryonic ste...

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Detalles Bibliográficos
Autores principales: Yin, Shanshan, Zhang, Fangyingnan, Lin, Song, Chen, Wei, Weng, Kai, Liu, Dan, Wang, Chuanle, He, Zibin, Chen, Yuxi, Ma, Wenbin, Huang, Junjiu, Huang, Yan, Songyang, Zhou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9120858/
https://www.ncbi.nlm.nih.gov/pubmed/35395177
http://dx.doi.org/10.1016/j.stemcr.2022.03.005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9120858/
https://www.ncbi.nlm.nih.gov/pubmed/35395177
http://dx.doi.org/10.1016/j.stemcr.2022.03.005

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