A rapid LC-MS/MS assay for detection and monitoring of underivatized branched-chain amino acids in maple syrup urine disease

INTRODUCTION: Quantitation of the isomeric branched-chain amino acids (BCAA; valine, alloisoleucine, isoleucine, leucine) is a challenging task that typically requires derivatization steps or long runtimes if a traditional chromatographic method involving a ninhydrin ion pairing reagent is used. OBJ...

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Detalles Bibliográficos
Autores principales: Piri-Moghadam, Hamed, Miller, Alan, Pronger, Debra, Vicente, Faye, Charrow, Joel, Haymond, Shannon, Lin, David C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9120951/
https://www.ncbi.nlm.nih.gov/pubmed/35602306
http://dx.doi.org/10.1016/j.jmsacl.2022.04.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9120951/
https://www.ncbi.nlm.nih.gov/pubmed/35602306
http://dx.doi.org/10.1016/j.jmsacl.2022.04.003

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