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Matrix reboot: IL-17 signals CAFs to create a second tumor T cell checkpoint
Excessive collagen deposition by fibroblasts surrounding some tumors has seriously limited the efficacy of checkpoint inhibitor therapies. Chen et al. (2022. J. Exp. Med. https://doi.org/10.1084/jem.20210693) show that IL-17 promotes collagen deposition by cancer-associated fibroblasts, enhancing im...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Rockefeller University Press
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9121177/ https://www.ncbi.nlm.nih.gov/pubmed/35583818 http://dx.doi.org/10.1084/jem.20220444 |