c-JUN inhibits mTORC2 and glucose uptake to promote self-renewal and obesity

Metabolic syndrome is associated with obesity, insulin resistance, and the risk of cancer. We tested whether oncogenic transcription factor c-JUN metabolically reprogrammed cells to induce obesity and cancer by reduction of glucose uptake, with promotion of the stemness phenotype leading to malignan...

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Detalles Bibliográficos
Autores principales: Serna, Raphael, Ramrakhiani, Ambika, Hernandez, Juan Carlos, Chen, Chia-Lin, Nakagawa, Chad, Machida, Tatsuya, Ray, Ratna B., Zhan, Xiaohang, Tahara, Stanley M., Machida, Keigo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9121277/
https://www.ncbi.nlm.nih.gov/pubmed/35601917
http://dx.doi.org/10.1016/j.isci.2022.104325

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9121277/
https://www.ncbi.nlm.nih.gov/pubmed/35601917
http://dx.doi.org/10.1016/j.isci.2022.104325

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