Targeting CISH enhances natural cytotoxicity receptor signaling and reduces NK cell exhaustion to improve solid tumor immunity

BACKGROUND: The success and limitations of current immunotherapies have pushed research toward the development of alternative approaches and the possibility to manipulate other cytotoxic immune cells such as natural killer (NK) cells. Here, we targeted an intracellular inhibiting protein ‘cytokine i...

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Detalles Bibliográficos
Autores principales: Bernard, Pierre-Louis, Delconte, Rebecca, Pastor, Sonia, Laletin, Vladimir, Costa Da Silva, Cathy, Goubard, Armelle, Josselin, Emmanuelle, Castellano, Rémy, Krug, Adrien, Vernerey, Julien, Devillier, Raynier, Olive, Daniel, Verhoeyen, Els, Vivier, Eric, Huntington, Nicholas D, Nunes, Jacques, Guittard, Geoffrey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Basic Tumor Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9121483/
https://www.ncbi.nlm.nih.gov/pubmed/35589278
http://dx.doi.org/10.1136/jitc-2021-004244

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9121483/
https://www.ncbi.nlm.nih.gov/pubmed/35589278
http://dx.doi.org/10.1136/jitc-2021-004244

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