Histone H3.3 K27M chromatin functions implicate a network of neurodevelopmental factors including ASCL1 and NEUROD1 in DIPG

BACKGROUND: The histone variant H3.3 K27M mutation is a defining characteristic of diffuse intrinsic pontine glioma (DIPG)/diffuse midline glioma (DMG). This histone mutation is responsible for major alterations to histone H3 post-translational modification (PTMs) and subsequent aberrant gene expres...

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Detalles Bibliográficos
Autores principales: Lewis, Nichole A., Klein, Rachel Herndon, Kelly, Cailin, Yee, Jennifer, Knoepfler, Paul S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9121554/
https://www.ncbi.nlm.nih.gov/pubmed/35590427
http://dx.doi.org/10.1186/s13072-022-00447-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9121554/
https://www.ncbi.nlm.nih.gov/pubmed/35590427
http://dx.doi.org/10.1186/s13072-022-00447-6

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