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NecroX-5 ameliorates bleomycin-induced pulmonary fibrosis via inhibiting NLRP3-mediated epithelial–mesenchymal transition

BACKGROUND: Pulmonary fibrosis is a progressive and usually lethal pulmonary disease. Despite considerable research efforts, no effective therapeutic strategy for pulmonary fibrosis has been developed. NecroX-5 has been reported to possess anti-inflammatory, anti-oxidative and anti-tumor activities....

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Detalles Bibliográficos
Autores principales: Min, Li, Shu-Li, Zhang, Feng, Yuan, Han, Hu, Shao-Jun, Li, Sheng-Xiong, Tong, Jia-Yu, Tian, Xiang-Zhi, Fang, Dan, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9121617/
https://www.ncbi.nlm.nih.gov/pubmed/35596212
http://dx.doi.org/10.1186/s12931-022-02044-3