CD4(+) T cells contribute to neurodegeneration in Lewy body dementia

Recent studies indicate that the adaptive immune system plays a role in Lewy body dementia (LBD). However, the mechanism regulating T cell brain homing in LBD is unknown. Here, we observed T cells adjacent to Lewy bodies and dopaminergic neurons in post-mortem LBD brains. Single-cell RNA sequencing...

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Detalles Bibliográficos
Autores principales: Gate, David, Tapp, Emma, Leventhal, Olivia, Shahid, Marian, Nonninger, Tim J., Yang, Andrew C., Strempfl, Katharina, Unger, Michael S., Fehlmann, Tobias, Oh, Hamilton, Channappa, Divya, Henderson, Victor W., Keller, Andreas, Aigner, Ludwig, Galasko, Douglas R., Davis, Mark M., Poston, Kathleen L., Wyss-Coray, Tony
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9122025/
https://www.ncbi.nlm.nih.gov/pubmed/34648304
http://dx.doi.org/10.1126/science.abf7266

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9122025/
https://www.ncbi.nlm.nih.gov/pubmed/34648304
http://dx.doi.org/10.1126/science.abf7266

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