Cargando…

Effective protection of ZF2001 against the SARS-CoV-2 Delta variant in lethal K18-hACE2 mice

To investigate the protective efficacy and mechanism of ZF2001 (a protein subunit vaccine with conditional approval in China) to SARS-CoV-2 Delta variant-induced severe pneumonia, the lethal challenge model of K18-hACE2 transgenic mice was used in this study. An inactivated-virus vaccine at the rese...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bian, Lianlian, Bai, Yu, Gao, Fan, Liu, Mingchen, He, Qian, Wu, Xing, Mao, Qunying, Xu, Miao, Liang, Zhenglun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Brief Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9122244/ https://www.ncbi.nlm.nih.gov/pubmed/35596222 http://dx.doi.org/10.1186/s12985-022-01818-x

Ejemplares similares

Transcriptomic analysis of the innate immune signatures of a SARS-CoV-2 protein subunit vaccine ZF2001 and an mRNA vaccine RRV
por: Wang, Qian, et al.
Publicado: (2022)

Prolonged Protective Immunity Induced by Mild SARS-CoV-2 Infection of K18-hACE2 Mice
por: Bar-On, Liat, et al.
Publicado: (2022)

Fatal Neurodissemination and SARS-CoV-2 Tropism in K18-hACE2 Mice Is Only Partially Dependent on hACE2 Expression
por: Carossino, Mariano, et al.
Publicado: (2022)

EV-A71 vaccine licensure: a first step for multivalent enterovirus vaccine to control HFMD and other severe diseases
por: Mao, Qunying, et al.
Publicado: (2016)

SARS-CoV-2 Delta variant induces enhanced pathology and inflammatory responses in K18-hACE2 mice
por: Lee, Katherine S., et al.
Publicado: (2022)

Effects of SARS-CoV-2 variants on vaccine efficacy and response strategies
por: Bian, Lianlian, et al.
Publicado: (2021)

Comparative pathology of the nasal epithelium in K18-hACE2 Tg mice, hACE2 Tg mice, and hamsters infected with SARS-CoV-2
por: Yu, Pin, et al.
Publicado: (2022)

Neutralisation of ZF2001-elicited antisera to SARS-CoV-2 variants
por: Zhao, Xin, et al.
Publicado: (2021)

Heterogeneous Infectivity and Pathogenesis of SARS-CoV-2 Variants Beta, Delta and Omicron in Transgenic K18-hACE2 and Wildtype Mice
por: Tarrés-Freixas, Ferran, et al.
Publicado: (2022)

Virulence Profiles of Wild-Type, P.1 and Delta SARS-CoV-2 Variants in K18-hACE2 Transgenic Mice
por: da Silva Santos, Yasmin, et al.
Publicado: (2023)

Delta (B1.617.2) variant of SARS-CoV-2 induces severe neurotropic patterns in K18-hACE2 mice
por: Yang, Ju-Hee, et al.
Publicado: (2023)

Therapeutic antibodies, targeting the SARS-CoV-2 spike N-terminal domain, protect lethally infected K18-hACE2 mice
por: Noy-Porat, Tal, et al.
Publicado: (2021)

Post-exposure protection of SARS-CoV-2 lethal infected K18-hACE2 transgenic mice by neutralizing human monoclonal antibody
por: Rosenfeld, Ronit, et al.
Publicado: (2021)

DNA immunization with in silico predicted T-cell epitopes protects against lethal SARS-CoV-2 infection in K18-hACE2 mice
por: Persson, Gry, et al.
Publicado: (2023)

Omicron SARS-CoV-2 Neutralization from Inactivated and ZF2001 Vaccines
por: Zhao, Xin, et al.
Publicado: (2022)

Non-neutralizing monoclonal antibody targeting VP2 EF loop of Coxsackievirus A16 can protect mice from lethal attack via Fc-dependent effector mechanism
por: Du, Ruixiao, et al.
Publicado: (2022)

Neuroinvasion and Neurotropism by SARS-CoV-2 Variants in the K18-hACE2 Mouse
por: Seehusen, Frauke, et al.
Publicado: (2022)

COVID-19 Treatments and Pathogenesis Including Anosmia in K18-hACE2 mice
por: Zheng, Jian, et al.
Publicado: (2020)

Research progress on vaccine efficacy against SARS-CoV-2 variants of concern
por: Bian, Lianlian, et al.
Publicado: (2022)

Evaluating Antibody Mediated Protection against Alpha, Beta, and Delta SARS-CoV-2 Variants of Concern in K18-hACE2 Transgenic Mice
por: Wong, Ting Y., et al.
Publicado: (2022)

Author Correction: Delta (B1.617.2) variant of SARS-CoV-2 induces severe neurotropic patterns in K18-hACE2 mice
por: Yang, Ju-Hee, et al.
Publicado: (2023)

A Novel Targeted RIG-I Receptor 5′Triphosphate Double Strain RNA-Based Adjuvant Significantly Improves the Immunogenicity of the SARS-CoV-2 Delta-Omicron Chimeric RBD-Dimer Recombinant Protein Vaccine
por: Bai, Yu, et al.
Publicado: (2023)

Evaluation of K18-hACE2 Mice as a Model of SARS-CoV-2 Infection
por: Moreau, Gregory Brett, et al.
Publicado: (2020)

Protocol for infecting and monitoring susceptible k18-hACE2 mice with SARS-CoV-2
por: Couto, Joana, et al.
Publicado: (2023)

K18-hACE2 mice develop respiratory disease resembling severe COVID-19
por: Yinda, Claude Kwe, et al.
Publicado: (2020)

K18-hACE2 mice develop respiratory disease resembling severe COVID-19
por: Yinda, Claude Kwe, et al.
Publicado: (2021)

Intranasal VLP-RBD vaccine adjuvanted with BECC470 confers immunity against Delta SARS-CoV-2 challenge in K18-hACE2-mice
por: Lee, Katherine S, et al.
Publicado: (2023)

BNT162b2 Vaccine Encoding the SARS-CoV-2 P2 S Protects Transgenic hACE2 Mice against COVID-19
por: Ji, Rui-Ru, et al.
Publicado: (2021)

Intranasal administration of BReC-CoV-2 COVID-19 vaccine protects K18-hACE2 mice against lethal SARS-CoV-2 challenge
por: Wong, Ting Y., et al.
Publicado: (2022)

Targeting 2-Oxoglutarate–Dependent Dioxygenases Promotes Metabolic Reprogramming That Protects against Lethal SARS-CoV-2 Infection in the K18-hACE2 Transgenic Mouse Model
por: Jessop, Forrest, et al.
Publicado: (2023)

COVID-19 Vaccines: Current Understanding on Immunogenicity, Safety, and Further Considerations
por: He, Qian, et al.
Publicado: (2021)

Neuroinvasion and Encephalitis Following Intranasal Inoculation of SARS-CoV-2 in K18-hACE2 Mice
por: Kumari, Pratima, et al.
Publicado: (2021)

Impact of Microbiota Depletion by Antibiotics on SARS-CoV-2 Infection of K18-hACE2 Mice
por: Rodrigues, Patrícia Brito, et al.
Publicado: (2022)

Human convalescent plasma protects K18-hACE2 mice against severe respiratory disease
por: Golden, Joseph W., et al.
Publicado: (2021)

Development of an ELISA Assay for the Determination of SARS-CoV-2 Protein Subunit Vaccine Antigen Content
por: Han, Lu, et al.
Publicado: (2022)

Efficacy and Safety of the RBD-Dimer–Based Covid-19 Vaccine ZF2001 in Adults
por: Dai, Lianpan, et al.
Publicado: (2022)

Preclinical Toxicity and Immunogenicity of a COVID-19 Vaccine (ZF2001) in Cynomolgus Monkeys
por: Yang, Hongzhong, et al.
Publicado: (2022)

Neutralization of SARS-CoV-2 omicron after BBIBP-CorV and ZF2001 booster vaccination
por: Zhang, Yuwei, et al.
Publicado: (2023)

An S1-Nanoparticle Vaccine Protects against SARS-CoV-2 Challenge in K18-hACE2 Mice
por: van Oosten, Linda, et al.
Publicado: (2022)

K18- and CAG-hACE2 Transgenic Mouse Models and SARS-CoV-2: Implications for Neurodegeneration Research
por: Dedoni, Simona, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_etto9v03u0so3nrsi84vjt98i3